Dose-response relation of liquid aerosol inhaled insulin in Type I diabetic patients
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چکیده
منابع مشابه
Rapid Publications Plasma (J-Thromboglobulin Response to Insulin-induced Hypoglycemia in Type I Diabetic Patients
The effect of an insulin-induced hypoglycemia was examined in 14 type I diabetic patients. After an overnight blood glucose normalization, each patient received an additional intravenous bolus of 3 U regular insulin at 0900 h (time 0). Blood glucose was continuously recorded up to 180 min. Plasma samples were assayed for p-thromboglobulin ((5TG, ng/ml), pancreatic glucagon (pg/ml), cortisol (|x...
متن کاملDose response of inhaled dry-powder insulin and dose equivalence to subcutaneous insulin lispro.
OBJECTIVE To determine the pharmacokinetic (PK) and glucodynamic (GD) dose response of human insulin inhalation powder (HIIP) delivered via AIR particle technology and dose equivalence to subcutaneous (SC) insulin lispro. RESEARCH DESIGN AND METHODS Twenty healthy, nonsmoking, male or female subjects (aged 29.6 +/- 6.9 years, BMI 23.2 +/- 2.3 kg/m2, means +/- SD) with normal forced vital capa...
متن کاملThe source of the circulating aggregate of insulin in type I diabetic patients is therapeutic insulin.
Circulating insulin immunoreactivity (IRI) in type I diabetic patients (insulin-dependent diabetes mellitus [IDDM]) includes a covalent aggregate about twice the size of insulin. These studies were designed to determine the source and conditions promoting the accumulation of this material. Among 31 IDDMs, the aggregate made up 28 +/- 3.6% of the mean fasting plasma IRI. Five of these patients w...
متن کاملDose-response relationships of inhaled insulin delivered via the Aerodose insulin inhaler and subcutaneously injected insulin in patients with type 2 diabetes.
OBJECTIVE To compare the dose-response relationship following inhalation of regular insulin delivered via the Aerodose insulin inhaler with that following subcutaneously injected regular insulin in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Twenty-four patients with type 2 diabetes (21 nonsmoking men, aged 36-80 years) each received two of three doses of 80, 160, or 240 units ...
متن کاملStudy of insulin resistance in relation to serum IGF-I levels in treated type-II diabetic patients.
Sir, Insulin resistance is a chronic metabolic syndrome characterized by a cluster of abnormalities including altered glucose tolerance, visceral adiposity, hypertension, low HDL cholesterol and high triglyceride levels, is linked with so many cardiovascular diseases.1 There is an increasing evidence has suggested that in the last few years, IGf-I may have a role in both glucose homeostasis and...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2001
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250051618